Article

Relational biological structure improves fine-mapping of causal GWAS variants under weak signal

2026-05-16

Abstract excerpt

Linkage disequilibrium (LD) makes causal GWAS variants indistinguishable from correlated neighbours; resolving them is the fine-mapping problem, and the challenge is species-specific: humans face dense ancestry-imbalanced LD, yeast and Arabidopsis exceptionally long LD, and crop germplasm sparse and fragmented annotations that defeat human-biobank curation pipelines. Bayesian fine-mappers integrate annotations as...

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Literature Corpus work: 60c513f6-7fde-5bb8-9484-4f92a2b51a43
DOI: 10.64898/2026.05.15.725513

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