Article

Meta-analysis fine-mapping is often miscalibrated at single-variant resolution

2022-03-20

Abstract excerpt

Meta-analysis is pervasively used to combine multiple genome-wide association studies (GWAS) into a more powerful whole. To resolve causal variants, meta-analysis studies typically apply summary statistics-based fine-mapping methods as they are applied to single-cohort studies. However, it is unclear whether heterogeneous characteristics of each cohort ( e . g ., ancestry, sample size, phenotyping, genotyping, o...

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Literature Corpus work: a8a7376c-f72b-5b26-96b2-45a72f2fe3aa
DOI: 10.1101/2022.03.16.22272457

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