Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of intratumoural heterogeneity in cancer drug resistance: molecular and clinical perspectives.

EMBO molecular medicine - 1 Aug 2012

Saunders Nicholas A, Simpson Fiona, Thompson Erik W, Hill Michelle M, Endo-Munoz Liliana, Leggatt Graham, Minchin Rodney F, Guminski Alexander

Abstract excerpt

Drug resistance continues to be a major barrier to the delivery of curative therapies in cancer. Historically, drug resistance has been associated with over-expression of drug transporters, changes in drug kinetics or amplification of drug targets. However, the emergence of resistance in patients treated with new-targeted therapies has provided new insight into the complexities underlying cancer drug resistance....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 22733553
DOI: 10.1002/emmm.201101131
PMCID: PMC3494067

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of intratumoural heterogeneity in cancer drug resistance: molecular and clinical perspectives.PMID 22733553Read ↗

Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistanceSemantic proximity Read ↗

Implications of intratumour heterogeneity for treatment stratification.Semantic proximity Read ↗

Tumour heterogeneity and the evolution of polyclonal drug resistance.Semantic proximity Read ↗

Intratumoral Cellular Heterogeneity: Implications for Drug Resistance in Patients with Non-Small Cell Lung CancerSemantic proximity Read ↗

Intra-tumour heterogeneity - going beyond genetics.Semantic proximity Read ↗

Cancer heterogeneity: implications for targeted therapeuticsSemantic proximity Read ↗

The challenge of intratumour heterogeneity in precision medicineSemantic proximity Read ↗

Drug Resistance in Cancers: A Free Pass for BullyingSemantic proximity Read ↗

Tumor heterogeneity and personalized cancer medicine: are we being outnumbered?Semantic proximity Read ↗

Intratumoral Heterogeneity: From Diversity Comes ResistanceSemantic proximity Read ↗

Not Everyone Fits the Mold: Intratumor and Intertumor Heterogeneity and Innovative Cancer Drug Design and Development.Semantic proximity Read ↗

A unifying framework disentangles genetic, epigenetic, and stochastic sources of drug-response variability in an <i>in vitro</i> model of tumor heterogeneitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.