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Article

Intra-tumour heterogeneity - going beyond genetics.

The FEBS journal - 1 Jun 2016

Caiado Francisco, Silva-Santos Bruno, Norell Håkan

Abstract excerpt

Cancer patients die primarily due to disease recurrence after transient treatment responses. The emergence of therapy-resistant escape variants is fuelled by intra-tumour heterogeneity, underpinned by interference and Darwinian evolution among continuously developing sub-clones in the mutating tumour. Novel cancer cell variants build upon the pre-existing genetic landscape and tumour heterogeneity is often...

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Share to Cell Lineage
Share to Epigenesis, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26945550
DOI: 10.1111/febs.13705

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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