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Inflammatory priming overrides Plasmodium falciparum cytoadhesion in reprogramming the human brain endothelial mRNA and microRNA landscape

2026-06-04

Abstract excerpt

<title>Abstract</title> <p> Sequestration of <italic>Plasmodium falciparum</italic> -infected erythrocytes in the microvasculature is a defining feature of severe malaria and has been closely associated with endothelial activation and vascular dysfunction. However, inflammatory mediators such as tumour necrosis factor alpha (TNF-α) are also abundant during infection and strongly influence endothelial signallin...

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Literature Corpus work
5b51ef26-585e-5109-be74-b4f198504c9c
DOI
10.21203/rs.3.rs-9913698/v1
Open publication

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Inflammatory priming overrides Plasmodium falciparum cytoadhesion in reprogramming the human brain endothelial mRNA and microRNA landscapeDOI 10.21203/rs.3.rs-9913698/v1
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