Article

Myeloid-derived immunosuppression of Chimeric Antigen Receptor T cells in the neuronal microenvironment of Glioblastoma

2025-08-08

Abstract excerpt

<title>Abstract</title> <p> Background Chimeric antigen receptor (CAR)-T cell therapy remains largely ineffective in glioblastoma (GB), where a highly immunosuppressive microenvironment and tumor heterogeneity impair therapeutic durability. Methods Using a human neocortical brain slice model that preserves the complex GB microenvironment, we profiled interactions between natural killer group 2D ( <italic>NKG2D<...

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Literature Corpus work: 5b3f6131-55a6-5d25-a893-23a7bf485f87
DOI: 10.21203/rs.3.rs-7240692/v1

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