Article

Proteostasis dysregulation is associated with astrocyte dysfunction and a KLF15–LRRTM4 regulatory axis in Alzheimer’s disease

2026-08-20

Abstract excerpt

<title>Abstract</title> <p>Proteostasis imbalance has been implicated in Alzheimer’s disease (AD) progression, yet its cross-cohort consistency and cell-type–specific mechanisms remain insufficiently characterized.This study aims to systematically profile proteostasis dysregulation in AD, identify interpretable diagnostic signatures, and pinpoint key cellular populations and potential regulatory axes at single-ce...

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Literature Corpus work: 4eee97ee-3f6f-5d33-bb7e-de69279dc238
DOI: 10.21203/rs.3.rs-10351234/v1

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