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Article

dHICA: a deep transformer-based model enables accurate histone imputation from chromatin accessibility.

Briefings in bioinformatics - 23 Sept 2024

Wen Wen, Zhong Jiaxin, Zhang Zhaoxi, Jia Lijuan, Chu Tinyi, Wang Nating, Danko Charles G, Wang Zhong

Abstract excerpt

Histone modifications (HMs) are pivotal in various biological processes, including transcription, replication, and DNA repair, significantly impacting chromatin structure. These modifications underpin the molecular mechanisms of cell-type-specific gene expression and complex diseases. However, annotating HMs across different cell types solely using experimental approaches is impractical due to cost and time...

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PMID: 39316943
DOI: 10.1093/bib/bbae459
PMCID: PMC11421843

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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