Article

NAD <sup>+</sup> metabolism is a key modulator of bacterial respiratory epithelial infections

2023-04-14

Abstract excerpt

1. <h4>Summary</h4> Lower respiratory tract infections caused by Streptococcus O pneumoniae (Spn) are a leading cause of death globally. Here we investigate the bronchial epithelial response to Spn infection on a transcriptomic, proteomic and metabolic level. We found the NAD + salvage pathway to be dysregulated upon infection in a cell line model, primary human lung tissue and in vivo in rodents, leading to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aa6daded-5a6c-5743-869a-65995b8b4e28
DOI: 10.1101/2023.04.13.536709

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

NAD <sup>+</sup> metabolism is a key modulator of bacterial respiratory epithelial infectionsDOI 10.1101/2023.04.13.536709Read

NAD+-targeting by bacteria: an emerging weapon in pathogenesisSemantic proximity Read

Pneumococcal H <sub>2</sub> O <sub>2</sub> Reshapes Mitochondrial Function and Reprograms Host Cell MetabolismSemantic proximity Read

Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis PathwaySemantic proximity Read

Treatment of SARS-CoV-2 induced pneumonia with NAD+ in a mouse modelSemantic proximity Read

Alterations in Nutrient Availability in the Lungs During <i>Streptococcus pneumoniae</i> -Induced PneumoniaSemantic proximity Read

Decoding NAD+ Metabolism in COVID-19: Implications for Immune Modulation and TherapySemantic proximity Read

NAD+ Degrading Enzymes, Evidence for Roles During InfectionSemantic proximity Read

Characterization of NAD salvage pathways and their role in virulence in Streptococcus pneumoniaeSemantic proximity Read

Genomics-driven reconstruction of acinetobacter NAD metabolism: insights for antibacterial target selection.Semantic proximity Read

The balance between NAD+ biosynthesis and consumption in ageingSemantic proximity Read

Niche-specific metabolic signatures in non-typeable <i>Haemophilus influenzae</i>Semantic proximity Read

Quinolinate salvage and insights for targeting NAD biosynthesis in group A streptococci.Semantic proximity Read