Article

Transcriptomic Profiling of Klebsiella pneumoniae Reveals Metabolic Adaptations to Meropenem Exposure

2025-07-07

Abstract excerpt

<h4>Background: </h4> Klebsiella pneumoniae is a major multidrug-resistant pathogen associated with severe hospital-acquired infections. Although meropenem remains a key therapeutic option, little is known about the global transcriptional response of K. pneumoniae to carbapenem exposure, especially in clinical isolates. <h4>Methods: </h4>: We performed RNA-sequencing (RNA-seq) on an extended-spectrum β-lactamase...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 26f22ea8-eb07-5b5b-a748-450d45a7951e
DOI: 10.22541/au.175189325.54376087/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptomic Profiling of Klebsiella pneumoniae Reveals Metabolic Adaptations to Meropenem ExposureDOI 10.22541/au.175189325.54376087/v1Read

Transcriptomic Remodeling and Survival Strategies of Extensively Drug-Resistant Klebsiella pneumoniae Under Meropenem PressureSemantic proximity Read

Transcriptomic Remodeling and Survival Strategies of Extensively Drug-Resistant Klebsiella pneumoniae Under Meropenem PressureSemantic proximity Read

Genome-scale metabolic modeling reveals increased reliance on valine catabolism in clinical isolates of <i>Klebsiella pneumoniae</i>Semantic proximity Read

Multi-omics investigations uncover unique pathogenic markers in clinical <i>Klebsiella pneumoniae</i> that could be leveraged as novel antimicrobial targetsSemantic proximity Read

Phenotypic and Transcriptomic Characterization of Host-Associated Responses in a Carbapenem-Resistant Klebsiella pneumoniae ST11 Clinical Isolate.Semantic proximity Read

Deep transcriptome profiling of clinical Klebsiella pneumoniae isolates reveals strain and sequence type-specific adaptation.Semantic proximity Read

Exogenous proline promotes serum killing of Klebsiella pneumoniaeSemantic proximity Read

A validated pangenome-scale metabolic model for the <i>Klebsiella pneumoniae</i> species complexSemantic proximity Read

Genomic and transcriptomic analyses of colistin-resistant clinical isolates of Klebsiella pneumoniae reveal multiple pathways of resistance.Semantic proximity Read

Global response to antibiotic exposure uncovers a critical role for nucleotide metabolism in high-level β-lactam toleranceSemantic proximity Read

Caerin 1.1/1.9 disrupts growth and biofilms of carbapenem-resistant Klebsiella pneumoniae with a transcriptomic signature of translational and metabolic stressSemantic proximity Read

Lysine acetylation regulates antibiotic resistance in <i>Escherichia coli</i>Semantic proximity Read