Back to search

Article

Oxidative reactions catalyzed by hydrogen peroxide produced by <i>Streptococcus pneumoniae</i> and other Streptococci Cause the Release and Degradation of Heme from Hemoglobin

2022-08-23

Abstract excerpt

Streptococcus pneumoniae (Spn) strains cause pneumonia that kills millions every year worldwide. Spn produces Ply, a hemolysin that lyses erythrocytes releasing hemoglobin and also produces the pro-oxidant hydrogen peroxide (Spn-H 2 O 2 ) during growth. The hallmark of the pathophysiology of hemolytic diseases is the oxidation of hemoglobin but oxidative reactions catalyzed by Spn-H 2 O 2 has been poorly studi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6d634ce2-217f-5691-ad55-17d10e44cee7
DOI
10.1101/2022.08.23.504964
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Oxidative reactions catalyzed by hydrogen peroxide produced by <i>Streptococcus pneumoniae</i> and other Streptococci Cause the Release and Degradation of Heme from HemoglobinDOI 10.1101/2022.08.23.504964
Hydrogen peroxide production by <i>Streptococcus pneumoniae</i> results in alpha-hemolysis by oxidation of oxy-hemoglobin to met-hemoglobinSemantic proximity
Endogenously produced H 2 O 2 is intimately involved in iron metabolism in Streptococcus pneumoniaeSemantic proximity
<i>Streptococcus pneumoniae</i> secretes hydrogen peroxide leading to DNA damage and apoptosis in lung cellsSemantic proximity
Pneumococcal H <sub>2</sub> O <sub>2</sub> Reshapes Mitochondrial Function and Reprograms Host Cell MetabolismSemantic proximity
Identification of hydrogen peroxide production-related genes in Streptococcus sanguinis and their functional relationship with pyruvate oxidase.Semantic proximity
Factors contributing to hydrogen peroxide resistance in Streptococcus pneumoniae include pyruvate oxidase (SpxB) and avoidance of the toxic effects of the fenton reaction.Semantic proximity
Hemoglobin stimulates vigorous growth of Streptococcus pneumoniae and shapes the pathogen's global transcriptome.Semantic proximity
The crimson conundrum: heme toxicity and tolerance in GAS.Semantic proximity
Spontaneous Mutants of <i>Streptococcus sanguinis</i> with Defects in the Glucose-PTS Show Enhanced Post-Exponential Phase FitnessSemantic proximity
Why do bacteria use so many enzymes to scavenge hydrogen peroxide?Semantic proximity
Pneumococcal Gene Complex Involved in Resistance to Extracellular Oxidative StressSemantic proximity
Interaction between Streptococcus pneumoniae and Staphylococcus aureus Generates·OH Radicals That Rapidly Kill Staphylococcus aureus StrainsSemantic proximity
Select a neighboring publication to make it the new centre.