Article

TIAR-dependent coordination of alternative splicing and lipid peroxidation is required for CML cell resistance to imatinib in the bone marrow stroma

2026-05-30

Abstract excerpt

<h4>ABSTRACT</h4> Chronic myeloid leukemia (CML) is treated with Abl1 tyrosine kinase inhibitors (TKIs). Quiescent cancer cells residing in the bone marrow (BM) can survive the treatment and cause CML relapse. We previously found that a subset of alternative splicing (AS) changes detected in CML cells surviving months of therapy are initiated within hours of treatment onset. Here, we investigated how AS in CML ce...

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Literature Corpus work: 5b108aef-519c-551a-b0f3-c5259948654b
DOI: 10.64898/2026.05.29.728710

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