Article

The Taurine-TauT Axis in Hematologic Malignancies: A Review on Redox Homeostasis, Mitochondrial tRNA Stabilization, Leukemic Stem Cell Persistence, and Therapeutic Vulnerabilities

2025-10-20

Abstract excerpt

Leukemia encompasses heterogeneous hematologic malignancies characterized by dysregulated hematopoiesis, metabolic reprogramming, and therapy resistance, with relapse driven by persistent leukemic stem cells (LSCs). This comprehensive review delineates the pivotal role of the taurine–TauT (SLC6A6) axis as a metabolic vulnerability across acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic mye...

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Literature Corpus work: 68a10f58-5cfb-53b4-b916-8e9f3213c527
DOI: 10.20944/preprints202510.1439.v1

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