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Understanding ER homeostasis and the UPR to enhance treatment efficacy of acute myeloid leukemia

8 Jul 2022

Abstract excerpt

Protein biogenesis, maturation and degradation are tightly regulated processes that are governed by a complex network of signaling pathways. The endoplasmic reticulum (ER) is responsible for biosynthesis and maturation of secretory proteins. Circumstances that alter cellular protein homeostasis, determine accumulation of misfolded and unfolded proteins in the ER, a condition defined as ER stress. In case of...

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PMID: 35870226
DOI: 10.1016/j.drup.2022.100853

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