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Synapsin-caveolin-1 mitigates cognitive deficits and neurodegeneration in Alzheimer’s disease mice

2020-07-25

Abstract excerpt

<h4>ABSTRACT</h4> AD presents with severe neurodegeneration which leads to cognitive deficits and dementia. Identifying the molecular signals that attenuate neurodegeneration in AD may be exploited as therapeutic targets. This study revealed that transgenic AD mice (PSAPP) exhibit decreased caveolin-1 (Cav-1), a membrane/lipid raft (MLR) scaffolding protein that organizes synaptic signaling components. Subcellula...

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Literature Corpus work
5b0f0b8b-1a8e-583d-a715-f084fee29356
DOI
10.1101/2020.07.24.220129
Open publication

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Synapsin-caveolin-1 mitigates cognitive deficits and neurodegeneration in Alzheimer’s disease miceDOI 10.1101/2020.07.24.220129
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