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Article

Reduction of synaptojanin 1 ameliorates synaptic and behavioral impairments in a mouse model of Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 31 Oct 2012

McIntire Laura Beth J, Berman Diego E, Myaeng Jennifer, Staniszewski Agnieszka, Arancio Ottavio, Di Paolo Gilbert, Kim Tae-Wan

Abstract excerpt

Decades of research have correlated increased levels of amyloid-β peptide (Aβ) with neuropathological progression in Alzheimer's disease (AD) patients and transgenic models. Aβ precipitates synaptic and neuronal anomalies by perturbing intracellular signaling, which, in turn, may underlie cognitive impairment. Aβ also alters lipid metabolism, notably causing a deficiency of phosphatidylinositol 4,5-bisphosphate...

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Identifiers

PMID: 23115165
DOI: 10.1523/JNEUROSCI.2034-12.2012
PMCID: PMC3711720

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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