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Article

Effect of Fluvoxamine on Amyloid-β Peptide Generation and Memory.

Journal of Alzheimer's disease : JAD - 1 Jan 2018

Kim Woojin Scott, Fu Yuhong, Dobson-Stone Carol, Hsiao Jen-Hsiang T, Shang Kani, Hallupp Marianne, Schofield Peter R, Garner Brett, Karl Tim, Kwok John B J

Abstract excerpt

Alzheimer's disease is characterized by abnormal amyloid-β (Aβ) peptide accumulation beginning decades before symptom onset. An effective prophylactic treatment aimed at arresting the amyloidogenic pathway would therefore need to be initiated prior to the occurrence of Aβ pathology. The SIGMAR1 gene encodes a molecular chaperone that modulates processing of the amyloid-β protein precursor (AβPP). Fluvoxamine is a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29614681
DOI: 10.3233/JAD-171001

Genes

SIGMAR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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