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Article

Age-related increase in caveolin-1 expression facilitates cell-to-cell transmission of α-synuclein in neurons

28 Jul 2021

Abstract excerpt

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease, with aging being considered the greatest risk factor for developing PD. Caveolin-1 (Cav-1) is known to participate in the aging process. Recent evidence indicates that prion-like propagation of misfolded α-synuclein (α-syn) released from neurons to neighboring neurons plays an important role in PD progression. In the present study,...

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PMID: 34321069
DOI: 10.1186/s13041-021-00834-2

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