Article
Neuron-specific caveolin-1 overexpression improves motor function and preserves memory in mice subjected to brain trauma.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2017
Egawa Junji, Schilling Jan M, Cui Weihua, Posadas Edmund, Sawada Atsushi, Alas Basheer, Zemljic-Harpf Alice E, Fannon-Pavlich McKenzie J, Mandyam Chitra D, Roth David M, Patel Hemal H, Patel Piyush M, Head Brian P
Abstract excerpt
Studies in vitro and in vivo demonstrate that membrane/lipid rafts and caveolin (Cav) organize progrowth receptors, and, when overexpressed specifically in neurons, Cav-1 augments neuronal signaling and growth and improves cognitive function in adult and aged mice; however, whether neuronal Cav-1 overexpression can preserve motor and cognitive function in the brain trauma setting is unknown. Here, we generated a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.