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Article

α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Jul 2011

Lim Youngshin, Kehm Victoria M, Lee Edward B, Soper James H, Li Chi, Trojanowski John Q, Lee Virginia M-Y

Abstract excerpt

Abnormally accumulated α-synuclein (α-syn) is a pathological hallmark of Lewy body-related disorders such as Parkinson's disease (PD) and dementia with Lewy body disease (DLB). However, it is not well understood whether and how abnormal accumulation of α-syn leads to cognitive impairment or dementia in PD and DLB. Furthermore, it is not known whether targeted removal of α-syn pathology can reverse cognitive...

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Identifiers

PMID: 21734300
DOI: 10.1523/JNEUROSCI.0618-11.2011
PMCID: PMC3144489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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