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Article

Single-Cell Profiling of AKI in a Murine Model Reveals Novel Transcriptional Signatures, Profibrotic Phenotype, and Epithelial-to-Stromal Crosstalk.

Journal of the American Society of Nephrology : JASN - 1 Dec 2020

Rudman-Melnick Valeria, Adam Mike, Potter Andrew, Chokshi Saagar M, Ma Qing, Drake Keri A, Schuh Meredith P, Kofron J Matthew, Devarajan Prasad, Potter S Steven

Abstract excerpt

BACKGROUND: Current management of AKI, a potentially fatal disorder that can also initiate or exacerbate CKD, is merely supportive. Therefore, deeper understanding of the molecular pathways perturbed in AKI is needed to identify targets with potential to lead to improved treatment. METHODS: We performed single-cell RNA sequencing (scRNA-seq) with the clinically relevant unilateral ischemia-reperfusion murine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33115917
DOI: 10.1681/ASN.2020010052
PMCID: PMC7790221

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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