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Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury

9 Sept 2022

Abstract excerpt

BACKGROUND: Acute kidney injury (AKI) occurs frequently in critically ill patients and is associated with adverse outcomes. Cellular mechanisms underlying AKI and kidney cell responses to injury remain incompletely understood. METHODS: We performed single-nuclei transcriptomics, bulk transcriptomics, molecular imaging studies, and conventional histology on kidney tissues from 8 individuals with severe AKI (stage...

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PMID: 36085050
DOI: 10.1186/s13073-022-01108-9

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