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Article

Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human Kidney

2025-09-28

Abstract excerpt

Building upon a foundational Human Kidney resource, we present a comprehensive multi-modal atlas that defines spatially resolved versus unresolved repair states and mechanisms in human kidney disease. Homeostatic interactions between injured kidney epithelium and its surrounding milieu determine successful repair outcomes, while pathogenic signaling promotes unresolved inflammation and fibrosis leading to chronic...

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Identifiers and source

Literature Corpus work
3f7b49e4-1e4e-50a3-9509-3e90092928fc
DOI
10.1101/2025.09.26.678707
Open publication

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Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human KidneyDOI 10.1101/2025.09.26.678707
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