Article

A conserved transcriptional backbone and rewiring of gene-regulatory networks in activated human CD4⁺ T cells

2025-11-27

Abstract excerpt

CD4+ T cells are components of the adaptive immune system with a plethora of subtype-specific functions. In order to further dissect the activation and differentiation regulatory program(s) of individual CD4+ T cell subsets, we performed an in vitro activation and differentiation of human primary naive CD4+ T cells towards Th1, Th2, Th17 and Treg subtypes followed by the single-cell RNA-seq and ATAC-seq (multiome)...

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Literature Corpus work: 5ae5f032-0738-5fad-827a-6c816d60e1cb
DOI: 10.1101/2025.11.25.687998

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