Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia.

doi:10.1016/j.stem.2017.01.009

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Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia.

Cell stem cell - 2 Mar 2017

Kotini Andriana G, Chang Chan-Jung, Chow Arthur, Yuan Han, Ho Tzu-Chieh, Wang Tiansu, Vora Shailee, Solovyov Alexander, Husser Chrystel, Olszewska Malgorzata, Teruya-Feldstein Julie, Perumal Deepak, Klimek Virginia M, Spyridonidis Alexandros, Rampal Raajit K, Silverman Lewis, Reddy E Premkumar, Papaemmanuil Elli, Parekh Samir, Greenbaum Benjamin D, Leslie Christina S, Kharas Michael G, Papapetrou Eirini P

Abstract excerpt

Myeloid malignancy is increasingly viewed as a disease spectrum, comprising hematopoietic disorders that extend across a phenotypic continuum ranging from clonal hematopoiesis to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). In this study, we derived a collection of induced pluripotent stem cell (iPSC) lines capturing a range of disease stages encompassing preleukemia, low-risk MDS, high-risk...

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Identifiers

PMID: 28215825
DOI: 10.1016/j.stem.2017.01.009
PMCID: PMC5337161

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