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Article

Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia.

Cell stem cell - 5 Oct 2017

Tothova Zuzana, Krill-Burger John M, Popova Katerina D, Landers Catherine C, Sievers Quinlan L, Yudovich David, Belizaire Roger, Aster Jon C, Morgan Elizabeth A, Tsherniak Aviad, Ebert Benjamin L

Abstract excerpt

Hematologic malignancies are driven by combinations of genetic lesions that have been difficult to model in human cells. We used CRISPR/Cas9 genome engineering of primary adult and umbilical cord blood CD34+ human hematopoietic stem and progenitor cells (HSPCs), the cells of origin for myeloid pre-malignant and malignant diseases, followed by transplantation into immunodeficient mice to generate genetic models of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28985529
DOI: 10.1016/j.stem.2017.07.015
PMCID: PMC5679060

Genes

TET2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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