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Studying clonal evolution of myeloid malignancies using induced pluripotent stem cells

1 Dec 2020

Abstract excerpt

PURPOSE OF REVIEW: Myeloid malignancies comprise a spectrum of genetically heterogeneous disorders marked by the stepwise acquisition of somatic mutations and clonal evolution. The blood and bone marrow of patients typically consists of a mix of different clones and subclones along the path of clonal evolution that cannot be deconvoluted with most current approaches. Here, we review the application of induced...

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PMID: 33264225
DOI: 10.1097/moh.0000000000000620

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