Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease.

Cell stem cell - 2 Mar 2017

Chao Mark P, Gentles Andrew J, Chatterjee Susmita, Lan Feng, Reinisch Andreas, Corces M Ryan, Xavy Seethu, Shen Jinfeng, Haag Daniel, Chanda Soham, Sinha Rahul, Morganti Rachel M, Nishimura Toshinobu, Ameen Mohamed, Wu Haodi, Wernig Marius, Wu Joseph C, Majeti Ravindra

Abstract excerpt

Understanding the relative contributions of genetic and epigenetic abnormalities to acute myeloid leukemia (AML) should assist integrated design of targeted therapies. In this study, we generated induced pluripotent stem cells (iPSCs) from AML patient samples harboring MLL rearrangements and found that they retained leukemic mutations but reset leukemic DNA methylation/gene expression patterns. AML-iPSCs lacked...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blast Crisis
Share to Cell Lineage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Shape

Share to Cellular Reprogramming

Share to Clone Cells

Share to Gene Expression Regulation, Leukemic

Share to Hematopoiesis

Share to Induced Pluripotent Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 28089908
DOI: 10.1016/j.stem.2016.11.018
PMCID: PMC5508733

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease.PMID 28089908Read ↗

Patient-Derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid LeukemiaSemantic proximity Read ↗

Reprogramming of Acute Myeloid Leukemia Patients Cells: Harboring Cancer Mutations Requires Targeting of AML Hierarchy.Semantic proximity Read ↗

Studying clonal evolution of myeloid malignancies using induced pluripotent stem cellsSemantic proximity Read ↗

Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells.Semantic proximity Read ↗

Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets.Semantic proximity Read ↗

Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of leukemiaSemantic proximity Read ↗

Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia.Semantic proximity Read ↗

Brief Report: Human Acute Myeloid Leukemia Reprogramming to Pluripotency Is a Rare Event and Selects for Patient Hematopoietic Cells Devoid of Leukemic Mutations.Semantic proximity Read ↗

Clonal evolution of pre-leukemic hematopoietic stem cells precedes human acute myeloid leukemia.Semantic proximity Read ↗

Biology and relevance of human acute myeloid leukemia stem cellsSemantic proximity Read ↗

Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency.Semantic proximity Read ↗

Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property, a requisite of leukemia initiation and relapse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.