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Normal and Cancerous Tissues Release Extrachromosomal Circular DNA (eccDNA) into the Circulation

26 May 2017

Abstract excerpt

Abstract Cell-free circulating linear DNA is being explored for noninvasive diagnosis and management of tumors and fetuses, the so-called liquid biopsy. Previously, we observed the presence of small extrachromosomal circular DNA (eccDNA), called microDNA, in the nuclei of mammalian tissues and cell lines. Now, we demonstrate that cell-free microDNA derived from uniquely mapping regions of the genome is detectable...

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PMID: 28550083
DOI: 10.1158/1541-7786.mcr-17-0095

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