Article

Endothelial cell RpL17-dependent translational control mediates intima-media thickening in response to disturbed flow

2026-05-25

Abstract excerpt

<h4>Background</h4> Carotid intima-media thickening (IMT) is a major risk factor for cardiovascular disease (CVD). The large ribosomal subunit protein 17 (Rpl17) was recently reported as a CVD-associated gene; however, ribosomal mutations generally are not associated with vascular dysfunction. We have created a novel genetic model of decreased RpL17 in endothelial cells (EC) to determine how changes in endothelia...

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Literature Corpus work: 5ab40672-4ee2-5d25-911b-e61550cd0d03
DOI: 10.64898/2026.05.21.726977

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