Article

Endothelial CXCL5 negatively regulates myelination and repair after white matter stroke

2019-06-10

Abstract excerpt

Cerebral small vessel disease and resulting white matter pathologies are worsened by cardiovascular risk factors including obesity. The molecular changes in cerebral endothelial cells caused by chronic cerebrovascular risk factors remain unknown. We developed a novel approach for molecular profiling of chronically injured cerebral endothelial cells using cell-specific translating ribosome affinity purification (Ri...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1ed56cdd-a621-56cd-b728-0ab197584196
DOI: 10.1101/664953

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Endothelial CXCL5 negatively regulates myelination and repair after white matter strokeDOI 10.1101/664953Read

Pericyte Loss Reprogrammes Capillary Endothelium and Drives White Matter Injury in Small Vessel DiseaseSemantic proximity Read

Vascular endothelium deploys caveolin-1 to regulate oligodendrogenesis after chronic cerebral ischemia in miceSemantic proximity Read

Multimodal characterization of the murine neurovascular niche using a novel microvascular isolation protocolSemantic proximity Read

Persistent Activation of Endothelial Cells is Linked to Thrombosis and Inflammation in Cerebral Cavernous Malformation DiseaseSemantic proximity Read

A Systems-Based Map of Human Brain Cell-Type Enriched Genes and Malignancy-Associated Endothelial ChangesSemantic proximity Read

Endothelial cell RpL17-dependent translational control mediates intima-media thickening in response to disturbed flowSemantic proximity Read

Single-Cell Transcriptomics Reveals Evidence of Endothelial Dysfunction in the Brains of COVID-19 Patients with Implications for Glioblastoma ProgressionSemantic proximity Read

Neuroinflammation plays a critical role in cerebral cavernous malformation diseaseSemantic proximity Read

The <i>in vivo</i> endothelial cell translatome is highly heterogeneous across vascular bedsSemantic proximity Read

RNA-Sequencing Highlights Inflammation and Impaired Integrity of the Vascular Wall in Brain Arteriovenous MalformationsSemantic proximity Read

Brain endothelial cells are exquisite sensors of age-related circulatory cuesSemantic proximity Read

Paraspeckles translate microbial insult-induced inflammation into neurovascular remodeling by enhancing CYR61-FGF2 signaling via RBM14 sequestrationSemantic proximity Read