Article

Exercise Mitigates Flow Recirculation and Activates Mechanosensitive Transcriptome to Uncover Endothelial SCD1-Catalyzed Anti-Inflammatory Metabolites

2023-05-04

Abstract excerpt

<h4>ABSTRACT</h4> Exercise modulates vascular plasticity in multiple organ systems; however, the metabolomic transducers underlying exercise and vascular protection in the disturbed flow-prone vasculature remain under-investigated. We simulated exercise-augmented pulsatile shear stress (PSS) to mitigate flow recirculation in the lesser curvature of the aortic arch. When human aortic endothelial cells (HAECs) were...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 324b377b-fbb4-5b1b-a031-e321035e08e2
DOI: 10.1101/2023.05.02.539172

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exercise Mitigates Flow Recirculation and Activates Mechanosensitive Transcriptome to Uncover Endothelial SCD1-Catalyzed Anti-Inflammatory MetabolitesDOI 10.1101/2023.05.02.539172Read

EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites through Endothelial Fatty Acid UptakeSemantic proximity Read

Flow-Mediated Modulation of the Endothelial Cell LipidomeSemantic proximity Read

Role of Flow-Sensitive Endothelial Genes in Atherosclerosis and Antiatherogenic Therapeutics Development.Semantic proximity Read

Integrated Multiomics Links Metabolic and Inflammatory Remodeling to Arterial Stiffness After the 4,486-km Trans Europe FootraceSemantic proximity Read

Atheroprone flow enhances the endothelial-to-mesenchymal transitionSemantic proximity Read

Fluid Mechanics, Arterial Disease, and Gene ExpressionSemantic proximity Read

Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculatureSemantic proximity Read

Endothelial cell RpL17-dependent translational control mediates intima-media thickening in response to disturbed flowSemantic proximity Read

Utilization of an <i>Artery-on-a-chip</i> to unravel novel regulators and therapeutic targets in vascular diseasesSemantic proximity Read

Endothelial heterogeneity associated with regional athero-susceptibility and adaptation to disturbed blood flow in vivo.Semantic proximity Read

Transcriptomic and Multi-scale Network Analyses Reveal Key Drivers of Cardiovascular DiseaseSemantic proximity Read

Stable Flow-induced Expression of KLK10 Inhibits Endothelial Inflammation and AtherosclerosisSemantic proximity Read