Article

Accurate detection of circulating tumor DNA using nanopore consensus sequencing

2020-07-15

Abstract excerpt

<h4>ABSTRACT</h4> Levels of circulating tumor DNA (ctDNA) in liquid biopsies may serve as a sensitive biomarker for real-time, minimally-invasive tumor diagnostics and monitoring. However, detecting ctDNA is challenging, as much fewer than 5% of the cell-free DNA in the blood typically originates from the tumor. To detect lowly abundant ctDNA molecules based on somatic variants, extremely sensitive sequencing met...

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Literature Corpus work: 5ab21dcd-4496-5386-8df6-7f1e0e9731ea
DOI: 10.1101/2020.07.14.202010

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