Article

Optimizing Accuracy and Efficiency in Analyzing Non-UMI Liquid Biopsy Datasets Using the Sentieon ctDNA Pipeline

2024-01-29

Abstract excerpt

Sequencing clinical liquid biopsy, especially circulating tumor DNA (ctDNA), provides a valuable method for identifying low allele frequency tumor variants, opening novel clinical applications, particularly in treatment selection for late-stage cancer patients. Despite advancements, challenges in assay development persist, primarily due to limited sample volumes and insufficiency of reads supporting low allele fre...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fc63b1ae-d0a0-545b-a3a6-c03f6c1e95ce
DOI: 10.1101/2024.01.24.577136

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Optimizing Accuracy and Efficiency in Analyzing Non-UMI Liquid Biopsy Datasets Using the Sentieon ctDNA PipelineDOI 10.1101/2024.01.24.577136Read

Processing UMI Datasets at High Accuracy and Efficiency with the Sentieon ctDNA Analysis PipelineSemantic proximity Read

Comprehensive benchmarking of methods for mutation calling in circulating tumor DNA.Semantic proximity Read

Comprehensive benchmarking of methods for mutation calling in circulating tumor DNASemantic proximity Read

Benchmarking UMI-aware and standard variant callers for low frequency ctDNA variant detection.Semantic proximity Read

TNscope: Accurate Detection of Somatic Mutations with Haplotype-based Variant Candidate Detection and Machine Learning FilteringSemantic proximity Read

Comparison of Target Enrichment Platforms for Circulating Tumor DNA Detection.Semantic proximity Read

Best practices for variant calling in clinical sequencing.Semantic proximity Read

TNER: A Novel Background Error Suppression Method for Mutation Detection in Circulating Tumor DNASemantic proximity Read

Accurate detection of circulating tumor DNA using nanopore consensus sequencingSemantic proximity Read

Method development for pancreatic and ovarian cancer baseline ctDNA detection and measurable residual disease monitoringSemantic proximity Read

PACT: a pipeline for analysis of circulating tumor DNA.Semantic proximity Read

A benchmarking study of individual somatic variant callers and voting-based ensembles for whole-exome sequencingSemantic proximity Read