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Article

Oncogene Concatenated Enriched Amplicon Nanopore Sequencing for rapid, accurate, and affordable somatic mutation detection.

Genome biology - 6 Sept 2021

Thirunavukarasu Deepak, Cheng Lauren Y, Song Ping, Chen Sherry X, Borad Mitesh J, Kwong Lawrence, James Phillip, Turner Daniel J, Zhang David Yu

Abstract excerpt

We develop the Oncogene Concatenated Enriched Amplicon Nanopore Sequencing (OCEANS) method, in which variants with low variant allele frequency (VAFs) are amplified and subsequently concatenated for Nanopore Sequencing. OCEANS allows accurate detection of somatic mutations with VAF limits of detection between 0.05 and 1%. We construct 4 distinct multi-gene OCEANS panels targeting recurrent mutations in acute...

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Identifiers

PMID: 34482832
DOI: 10.1186/s13059-021-02449-1
PMCID: PMC8419911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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