Article

Rapid identification of genomic structural variations with nanopore sequencing enables blood-based cancer monitoring

2019-11-15

Abstract excerpt

Somatic genomic structural variations (SVs) are promising personalized biomarkers for sensitive and specific detection of circulating tumor DNA (ctDNA) in liquid biopsies. However, affordable and fast identification of such SV biomarkers is challenging, which hinders routine use in the clinic. Here, we developed a novel approach - termed SHARC - for rapid discovery of somatic SVs as personalized tumor biomarkers....

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Literature Corpus work: a2d3e208-f179-550d-ba45-291576c3c358
DOI: 10.1101/19011932

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