SnRNA-seq reveals differential functional transcriptional pathway alterations in three mutant types of dilated cardiomyopathy.

Abstract excerpt

Dilated cardiomyopathy (DCM) is a leading cause of heart failure, characterized by ventricular dilation, thinning of the ventricular walls, and systolic dysfunction in either the left or both ventricles, often accompanied by fibrosis. Human cardiac tissue is composed of various cell types, including cardiomyocytes (CMs), fibroblasts (FBs), endothelial cells (ECs), macrophages, lymphocytes and so on. In DCM...

Topics

• Cardiomyopathy, Dilated
• Humans
• Mutation
• Signal Transduction
• Myocytes, Cardiac
• Gene Expression Regulation
• Transcription, Genetic
• Connectin