Article

Proteins with amino acid repeats constitute rapidly evolvable and human-specific essentialome

2022-12-30

Abstract excerpt

Protein products of essential genes, indispensable for organismal survival, are highly conserved and bring about fundamental functions. Interestingly, proteins that contain amino acid homorepeats that tend to evolve rapidly are enriched in eukaryotic essentialomes. Why are proteins with hypermutable homorepeats enriched in conserved and functionally vital essential proteins? We solve this function versus evolution...

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Literature Corpus work: 5a81eb0c-46e8-5ef8-990f-d8907ef1dfc2
DOI: 10.1101/2022.12.29.521938

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