Article

Comprehensive prediction and analysis of human protein essentiality based on a pre-trained protein large language model

2024-03-29

Abstract excerpt

Human essential genes and their protein products are indispensable for the viability and development of the individuals. Thus, it is quite important to decipher the essential proteins and up to now numerous computational methods have been developed for the above purpose. However, the current methods failed to comprehensively measure human protein essentiality at levels of humans, human cell lines, and mice ortholo...

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Literature Corpus work: eaaf6fcf-ebd1-5dc5-b9db-9773e18c92a8
DOI: 10.1101/2024.03.26.586900

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