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Article

Non-random distribution of homo-repeats: links with biological functions and human diseases.

Scientific reports - 3 Jun 2016

Lobanov Michail Yu, Klus Petr, Sokolovsky Igor V, Tartaglia Gian Gaetano, Galzitskaya Oxana V

Abstract excerpt

The biological function of multiple repetitions of single amino acids, or homo-repeats, is largely unknown, but their occurrence in proteins has been associated with more than 20 hereditary diseases. Analysing 122 bacterial and eukaryotic genomes, we observed that the number of proteins containing homo-repeats is significantly larger than expected from theoretical estimates. Analysis of statistical significance...

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Identifiers

PMID: 27256590
DOI: 10.1038/srep26941
PMCID: PMC4891720

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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