Article
Further understanding human disease genes by comparing with housekeeping genes and other genes.
BMC genomics - 21 Feb 2006
Tu Zhidong, Wang Li, Xu Min, Zhou Xianghong, Chen Ting, Sun Fengzhu
Abstract excerpt
BACKGROUND: Several studies have compared various features of heritable disease genes with other so called non-disease genes, but they have yielded some conflicting results. A potential problem in those studies is that the non-disease genes contained a large number of essential genes--genes which are indispensable for humans to survive and reproduce. Since a functional disruption of an essential gene has fatal...
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