Article

MYC overrides HIF to regulate proliferating primary cell metabolism in hypoxia

2020-09-21

Abstract excerpt

<h4>ABSTRACT</h4> Hypoxia requires metabolic adaptations to sustain energetically demanding cellular activities. While the metabolic consequences of hypoxia have been studied extensively in cancer cell models, comparatively little is known about the metabolic response of primary cells to hypoxia. We performed metabolic flux analyses of proliferating human lung fibroblasts and pulmonary artery smooth muscle cells...

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Literature Corpus work: a3fc8525-34b3-5490-a797-b7576df3c6ac
DOI: 10.1101/2020.09.21.306464

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