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Article

Metabolism in tumour-associated macrophages: a quid pro quo with the tumour microenvironment.

European respiratory review : an official journal of the European Respiratory Society - 30 Sept 2020

Zheng Xiang, Mansouri Siavash, Krager Annika, Grimminger Friedrich, Seeger Werner, Pullamsetti Soni S, Wheelock Craig E, Savai Rajkumar

Abstract excerpt

Lung cancer is the leading cause of death from cancer worldwide. Recent studies demonstrated that the tumour microenvironment (TME) is pivotal for tumour progression, providing multiple targeting opportunities for therapeutic strategies. As one of the most abundant stromal cell types in the TME, tumour-associated macrophages (TAMs) exhibit high plasticity. Malignant cells alter their metabolic profiles to adapt...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33004525
DOI: 10.1183/16000617.0134-2020
PMCID: PMC9488699

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