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Structure and function of the Zika virus full-length NS5 protein

27 Mar 2017

Abstract excerpt

The recent outbreak of Zika virus (ZIKV) has infected over 1 million people in over 30 countries. ZIKV replicates its RNA genome using virally encoded replication proteins. Nonstructural protein 5 (NS5) contains a methyltransferase for RNA capping and a polymerase for viral RNA synthesis. Here we report the crystal structures of full-length NS5 and its polymerase domain at 3.0 Å resolution. The NS5 structure has...

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PMID: 28345656
DOI: 10.1038/ncomms14762

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