Disrupting IFIT1-STAT2 viral evasion synergy yields live-attenuated flavivirus with enhanced immune priming

Abstract excerpt

Diverse human viruses deploy a common immune-evasion strategy: viral 2’-O-methylation coupled with STAT2 antagonism. Yet the importance of this coupling and whether targeting the coupled functions offers benefits in vaccine development, remains unknown. Using deep mutational scanning of the dengue NS5 protein, we discovered that the two immune-evasion functions work synergistically to cripple interferon signaling....

Topics

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• Cytomegalovirus and herpesvirus research
• HIV Research and Treatment
• Immune Cell Function and Interaction
• interferon and immune responses
• Mosquito-borne diseases and control
• SARS-CoV-2 and COVID-19 Research
• Vaccine Coverage and Hesitancy
• Viral Infections and Vectors

Identifiers and source

Literature Corpus work

9b1e9aa9-e4c9-5abe-848a-44f499fbf2db

DOI

10.64898/2026.06.04.729841