Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution of STAT2 resistance to flavivirus NS5 occurred multiple times despite genetic constraints

26 Jun 2024

Abstract excerpt

Zika and dengue virus nonstructural protein 5 antagonism of STAT2, a critical interferon signaling transcription factor, to suppress the host interferon response is required for viremia and pathogenesis in a vertebrate host. This affects viral species tropism, as mouse STAT2 resistance renders only immunocompromised or humanized STAT2 mice infectable. Here, we explore how STAT2 evolution impacts antagonism. By...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Malaria Research and Control
Share to Mosquito-borne diseases and control
Share to Viral Infections and Vectors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38926343
DOI: 10.1038/s41467-024-49758-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of STAT2 resistance to flavivirus NS5 occurred multiple times despite genetic constraintsPMID 38926343Read ↗

Coevolutionary constraints of Zika virus nonstructural protein 5 replication and interferon antagonism activitiesSemantic proximity Read ↗

A conformational selection mechanism of flavivirus NS5 for species-specific STAT2 inhibitionSemantic proximity Read ↗

The Many Faces of the Flavivirus NS5 Protein in Antagonism of Type I Interferon SignalingSemantic proximity Read ↗

Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races.Semantic proximity Read ↗

Host-Virus Arms Races Drive Elevated Adaptive Evolution in Viral Receptors.Semantic proximity Read ↗

Weapons of STAT destructionSemantic proximity Read ↗

A tunable immune-evasion function of Zika virus NS5 governs viral fitness and pathogenesisSemantic proximity Read ↗

Pervasive Positive Selection on Virus Receptors Driven by Host-Virus Conflicts in Mammals.Semantic proximity Read ↗

Structural basis for STAT2 suppression by flavivirus NS5Semantic proximity Read ↗

Convergent Evolution of Escape from Hepaciviral Antagonism in PrimatesSemantic proximity Read ↗

Host and Viral Determinants of Mx2 Antiretroviral ActivitySemantic proximity Read ↗

Host-Specific NS5 Ubiquitination Determines Yellow Fever Virus TropismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.