Article

<i>Rock2</i> heterozygosity improves cognitive behavior and endothelial function in a mouse model of 16p11.2 deletion autism syndrome

2024-06-25

Abstract excerpt

<h4>ABSTRACT</h4> Rho-associated coiled-coil containing protein kinase-2 (ROCK2) is a critical player in many cellular processes and has been incriminated in cardiovascular and neurological conditions. Recent evidence has shown that non-selective pharmacological ROCK inhibition ameliorates behavioral alterations in an autism mouse model of 16p11.2 haploinsufficiency. We had also revealed that 16p11.2-deficient mi...

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Literature Corpus work: 5a6c2e0c-a820-59fa-9e8d-890472bde32c
DOI: 10.1101/2024.06.24.600440

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