Article

Targeting the RHOA pathway improves learning and memory in <i>Kctd13</i> and 16p11.2 deletion mouse models

2020-05-24

Abstract excerpt

<h4>ABSTRACT</h4> Gene copy number variants (CNV) have an important role in the appearance of neurodevelopmental disorders. Particularly, the deletion of the 16p11.2 locus is associated with autism spectrum disorder, intellectual disability, and several other features. Earlier studies highlighted the implication of Kctd13 genetic imbalance in the 16p11.2 deletion through the regulation of the RHOA pathway. Here,...

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Literature Corpus work: 6ce57d79-4a78-5bcf-a572-3a825df1cc3e
DOI: 10.1101/2020.05.22.110098

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