Article

Rac1 contributes to brain connectivity impairments and neuropsychiatric disorders in Tuberous Sclerosis Complex

2025-12-11

Abstract excerpt

Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder caused by inactivating mutations in the TSC1 or TSC2 genes, leading to constitutive activation of the mTOR complex 1 pathway. Patients commonly present with epilepsy and TSC-associated neuropsychiatric disorders (TANDs), including intellectual disability and anxiety. Our previous work identified anxiety-like behavior in tsc2 vu242 zebrafish muta...

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Literature Corpus work: 876480d2-7f73-508f-9609-1ff961bd92a3
DOI: 10.64898/2025.12.09.693152

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