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Towards Preclinical Validation of Arbaclofen (R-baclofen) Treatment for 16p11.2 Deletion Syndrome

2023-05-02

Abstract excerpt

A microdeletion on human chromosome 16p11.2 is one of the most common copy number variants associated with autism spectrum disorder and other neurodevelopmental disabilities. Arbaclofen, a GABA(B) receptor agonist, is a component of racemic baclofen, which is FDA-approved for treating spasticity, and has been shown to alleviate behavioral phenotypes, including recognition memory deficits, in animal models of 16p11...

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Literature Corpus work
5902f0ed-8e45-5887-99aa-347cb512433e
DOI
10.1101/2023.05.01.538987
Open publication

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Towards Preclinical Validation of Arbaclofen (R-baclofen) Treatment for 16p11.2 Deletion SyndromeDOI 10.1101/2023.05.01.538987
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